Publications
q q "An Electron Trap for DNA-bound Repair Enzymes: A Strategy for DNA-mediated Signaling,"
Yavin, E., Stemp, E.D.A., O’Shea, V.L., David, S. S., Barton, J.K., Proc. Natl. Acad. Sci, USA, 2006 Mar 7;
103(10): 3610-4.
q q "Insight into the Role of Tyrosine 82 and Glycine 253 in the Escherichia coli Adenine Glycosylase
MutY, " Livingston, A.L., Kundu, S., Pozzi, M.H., Anderson, D.W., David,
S. S., Biochemistry, 2005, 44,
14179-14190
q q "DNA-bound Redox Activity of DNA Repair Glycosylases Containing
[4Fe-4S] Clusters, " Boal, A.K., Yavin, E., Lukianova, O.A., O’Shea, V.L.,
David, S.S., Barton, J.K., Biochemistry 2005, 44, 8397-8407
q q "DNA Search and Rescue,”New
and Views, David, S.S., Nature,
2005, 453, 569-570.
q q "A Role for Iron-Sulfur Clusters in DNA Repair,” Lukianova, O.A.,
David, S. S.,
Curr. Op.
Chem. Biol., 2005, 9, 145-151.
q q "Protein-DNA Charge Transport:
Redox Activation of a DNA Repair Protein by Guanine Radical, “ Yavin,
E., Boal, A. K., Stemp, E. D.A., Boon,
E.M., Livingston, A.L., O’Shea, V.L., David, S.S., Barton, J.K., Proc. Natl. Acad. Sci. USA, 2005, 102, 3552-3557.
q q "Insight into the functional consequences
of hMYH variants associated with colorectal cancer: Distinct differences in the
adenine glycosylase activity and the response to AP endonucleases of Y150C and
G365D murine MYH," Pope, M.A., Chmiel, N.H., David, S.S., DNA Repair, 2005, 4, 315-325. 38.
q q "DNA Damage Recognition and Repair by the Murine MutY Homologue,”
Pope, M.A., David, S. S., DNA Repair,
2005, 4, 91-102.
q q "A Residue in MutY Important for Catalysis Identified by
Photocross-Linking and Mass Spectrometry, " Chepanoske, C. L., Lukianova,
O. A., Lombard, M., Golinelli-Cohen, M.-P., David, S. S., Biochemistry, 2004, 43,
651-662.
q q "Probing the Requirements for Recognition and Catalysis in Fpg and
MutY With Nonpolar Adenine Isosteres, " Francis, A. W., Helquist, S. A.,
Kool, E. T., David, S. S., J. Am. Chem.
Soc, 2003, 125, 16235-16242.
q
q
"DNA-mediated Charge
Transport for DNA Repair,” Boon, E. M., Livingston, A. L., Chmiel, N. H.,
David, S. S., Barton, J. K., Proc. Natl.
Acad. Sci. U.S.A 2003, 100, 12543-12547.
q q "Recognition and Removal of Oxidized Guanines in Duplex DNA by the
Base Excision Repair Enzymes hOGG1, yOGG1 and yOGG2, " Leipold, M. D.,
Workman, H., Muller, J.G., Burrows, C. J., David, S. S., Biochemistry, 2003, 42, 11373-11381.
q q "Repair of DNA
Containing Fapy•dG and its b-C-Nucleoside Analogue by Formamidopyrimidine DNA
Glycosylase and MutY, " Wiederhold, C.J., Delaney, M.O., Pope, M.A.,
David, S. S., Greenberg, M.M., 2003, 42, 9755-9760.
q q "Inherited variants of hMYH associated with colorectal cancer
exhibit a compromised ability to recognize and repair A:OG
(7,8-dihydro-8-oxo-2’-deoxyguanosine) mismatches in DNA,” Chmiel, N.H.;
Livingston, A.L.; David, S.S., Journal of
Molecular Biology, 2003, 327, 431-443.
q
q
"Escherichia coli MutY and Fpg Utilize a Processive Mechanism for
Target Location,” Francis, A. W. and David, S. S., Biochemistry, 2003, 42,
801-810.
q q "Structural Elucidation and Potential Mutagenicity of New Hydantoin
Products from Guanosine and 8-oxo-7,8-dihydroguanosine Oxidation by Transition
Metals," Burrows, C.J.; Muller,
J.G.; Kornyshyna, O.; Luo, W.; Duarte, V.; Leipold, M.D.; David, S.S., Environ. Health Perspect. , 2002, 110, 713-717.
q q "DNA-Mediated Charge Transport as a Probe of MutY-DNA
Interaction," Boon, E. M.; Pope, M. A.; Williams, S.D.; David, S. S.;
Barton, J.K., Biochemistry, 2002, 41, 8464-8470.
q q "E. coli AP Endonucleases
Enhance the Turnover of the Adenine Glycosylase MutY with G:A
Substrates," Pope, M. A.; Porello,
S. L.; David, S. S., J. Biol. Chem.,2002,
277, 22605-22615.
q q "Noncysteinyl coordination to the [4Fe-4S]2+ Cluster of
the DNA Repair Adenine Glycosylase MutY introduced via Site-Directed
Mutagenesis. Structural
Characterization of an Unusual Histidinyl Coordinated Cluster," Messick,
T. E.; Chmiel, N. H.; Golinelli, M.-P.; Langer, M. R.: Joshua-Tor, L.; David,
S.S., Biochemistry, 2002, 41, 3931-3942.
q q "Inherited Variants of hMYH
associated with somatic G:C ® T:A mutations in colorectal tumours," Al-Tassan, N.; Chmiel, N.H.; Maynard, J.; Fleming, N.; Livingston, A.L.;
Williams, G.T.; Hodges, A.K.; Rhodri-Davies, D.; David, S. S.; Sampson, J.R.
and Cheadle, J.P., Nature Genetics,
2002, 30, 227-232.
q q "Efficient Recognition of Substrates and Substrate Analogs by the
Adenine Glycosylase MutY Requires the C-terminal Domain," Chmiel, N.H.;
Golinelli, M.-P.; Francis, A.W. and David, S. S., Nucleic Acids Res., 2001, 29,
533-564.
q q "The Removal of Hydantoin Products of 8-Oxoguanine Oxidation by the E. coli DNA Repair Enzyme, Fpg,"
Leipold, M. D.; Muller, J.G.; Burrows, C. J. and David, S. S., Biochemistry, 2000, 39, 14984-14992.
q q "A Single Engineered Point Mutation in the Adenine Glycosylase MutY
Confers Bifunctional Glycosylase/AP Lyase Activity, " Williams, S.D. and
David, S.S., Biochemistry, 2000, 39, 10098-10109.
q q "Positively Charged Residues within the Iron-Sulfur Cluster Loop of E. coli MutY Participate in Damage
Recognition and Removal," Chepanoske, C. L.; Golinelli, M.P.; Williams, S.
D. and David, S. S., Arch. Biochem.
Biophys., 2000, 380, 11-19.
q q "Recognition of the Nonpolar Base 4-Methylindole in DNA by the DNA
Repair Adenine Glycosylase MutY," Chepanoske, C. L.; Langelier, C. R.;
Chmiel, N.H. and David, S.S. Org. Lett, 2000, 2, 1341-1344.
q q "Formation of a Schiff base Intermediate is not Required for the
Adenine Glycosylase Activity of E. coli
MutY," Williams, S. D. and David, S. S.
Biochemistry, 1999, 38,
15417-15424.
q q "Mechanism-Based DNA-Protein Cross-Linking Of MutY via Oxidation of
8-Oxoguanosine, " Hickerson, R.
P.; Chepanoske, C. L.; Williams, S. D.; David, S.S. and Burrows, C. J., J. Am. Chem. Soc.,1999, 121,
9901-9902
q q "Substrate Recognition by E.
coli MutY using Substrate Analogs," Chepanoske, C. L.; Porello, S. L.; Fujiwara, T.;
Sugiyama, H. and David, S. S., Nucleic
Acids Res. 1999, 27, 3197-3204
q q "Site-Directed Mutagenesis of the Cysteine Ligands to the [4Fe-4S]
Cluster of Escherichia coli MutY,
"Golinelli, M.P.; Chmiel, N.H. and David, S.S., Biochemistry, 1999, 38, 6997-7007.
q q "Evidence that MutY is a Monofunctional Glycosylase that is Capable
of Forming a Covalent Schiff Base Intermediate with Substrate DNA, “ Williams,
S. D. and David, S. S., Nucleic Acids
Res., 1998, 26, 5123-5133.
q q "Single-Turnover and Pre-Steady State Kinetics of the Reaction of
the Adenine Glycosylase MutY with Mismatch-Containing DNA Substrates,"
Porello, S. L.; Leyes, A. E. and David, S.S., Biochemistry, 1998, 371, 14756-14764.
q q "A Substrate Recognition Role for the [4Fe-4S] Cluster in the DNA
Repair Glycosylase, MutY," Porello, S. L.; Cannon, M.J. and David, S. S. Biochemistry, 1998, 37, 6465-6475.
q q "Chemistry of Glycosylases and Endonucleases Involved in
Base-Excision Repair," David, S. S. and Williams, S. D., Chem. Rev., 1998, 98, 1221-1261
q q "Specific Recognition of Substrate Analogs by the DNA Mismatch
Repair Enzyme MutY," Porello, S. L.; Williams, S. D.; Kuhn, H.; Michaels,
M.L. and David, S. S., J. Am. Chem. Soc.,
1996, 118, 10684-10692
q q "Synthesis and Characterization of 8-Methoxy-2'-deoxyadenosine
Containing Oligonucleotides to Probe the Syn
Glycosidic Conformation of 2'-Deoxyadenosine within DNA," Eason, R.G.;
Burkhardt, D.M.; Phillips, S.J.; Smith, D.P. and David, S.S., Nucleic Acids Res. 1996, 24, 890-897.
q q "An Efficient
Synthesis of 2'-Deoxyformycin A Containing Oligonucleotides and
Characterization of their Stability in Duplex DNA," Kuhn, H.; Smith, D.P.
and David, S.S., J. Org. Chem., 1995,
60, 7094-7095.