Professor Dale Poulter

Professor C. Dale Poulter

Education

  • B.S., 1964, Louisiana State University (Cum Laude)
  • Ph.D., 1967, University of California at Berkeley, with W.G. Dauben
  • Postdoctoral, 1967-69, University of California at Los Angeles, with S. Winstein

Contact

Office: HEB 2274

Phone: 801.581.6685

Email:poulter@chem.utah.edu

Awards

  • Honorary Professor, University of Queensland, Brisbande, Australia, 2002-2004
  • Repligen Award, Biological Division, American Chemical Society, 2002
  • Wilsmore Fellow, Melbourne University, 2001
  • Rosenblatt Award, University of Utah, 1999
  • Arthur C. Cope Scholar Award, American Chemical Society, 1998
  • Governor's Medal for Science and Technology, 1995
  • National Institutes of Health Merit Award, 1995
  • Fellow, American Association for the Advancement of Science, 1994
  • Utah Award, American Chemical Society, 1992
  • Ernest Guenther Award, American Chemical Society, 1991
  • Distinguished Research Award, University of Utah, 1984
  • David P. Gardner Faculty Fellow, 1983
  • Alfred P. Sloan Fellow, 1975-79
  • NIH Career Development Awardee, 1975-80
  • NIH Postdoctoral Fellow, 1967-69
  • NIH Predoctoral Fellow, 1965-67
  • Omnicron Delta Kappa, 1964
  • Phi Lambda Upsilon, 1964
  • Phi Kappa Phi, 1964

Professional Positions

  • Distinguished Professor of Chemistry, University of Utah, 1996-present
  • Chair, Department of Chemistry, University of Utah, 1995-2000
  • John A. Widtsoe Professor of Chemistry, University of Utah, 1994-present
  • Research Professor, Department of Medicinal Chemistry, University of Utah, 1978-present
  • Adjunct Professor, Department of Biochemistry, University of Utah, 1986-present
  • Professor, Department of Chemistry, University of Utah, 1978-1994
  • Director, Interdepartmental Program in Biological Chemistry, 1990-1993
  • Associate Professor, Department of Chemistry, University of Utah, 1975-1978
  • Associate Research Professor, Department of Biopharmaceutical Sciences, University of Utah, 1975-1978
  • Assistant Professor, Department of Chemistry, University of Utah, 1969-1975
  • Assistant Research Professor, Department of Biopharmaceutical Sciences, University of Utah, 1971-1975
  • Chemist, Esso Research Laboratory, Baton Rouge, Louisiana, Summer 1964
  • Chemist, PPG Chemicals, Lake Charles, Louisiana, Summers, 1962, 1963

Professional Activities

  • NAS, Bio2010, Chemistry sub-committee, 2001
  • AAAS, Member-at-Large, 2001-present
  • CS, Advisory Committee on Graduate Education, 2000-present
  • ACS, Committee on Professional Training, 1996-present
  • ACS, Councilor, Biological Division, 1993-present
  • AAAS, Nominating Committee Chemistry Division, 1997-1999, Chair 1999
  • ACS, Chair of Organic Division, 1998
  • ACS, Selection Committee; Editor of Organic Letters, 1998
  • ACS, Committee on Science, 1996-1999
  • NSF, Workshop on Organic Synthesis and Natural Products, co-organizer, 1993-1995
  • 14th Enzyme Mechanisms Conference, Scottsdale, AZ, Chair, 1993-95
  • 13th Enzyme Mechanisms Conference, Key Largo, FL, organizing committee, 1991-97
  • NIH, General Medical Sciences Council, 1990
  • ACS, American Coordinator, Biological Program, Pacific Basin Chemical Congress, 1989, 1995
  • PRF, Advisory Board, 1988-1990
  • ACS, Selection Committee; Editor of Journal of Organic Chemistry, 1988
  • ACS, Program Chairman for Biological Division, 1987
  • ACS, Canvassing Committee, Roger Adams Award in Organic Chemistry, 1986-1990
  • Gordon Conference on Enzymes, Coenzymes, and Metabolic Pathways, Chair, 1985
  • ACS, Executive Committee Organic Division, 1983-1986
  • NAS, Workshop on Effort Reporting Requirements of OMB Circular A-21; 1983
  • NIH, Ad Hoc member and Special Study Sections; 1980-1993
  • 7th Enzyme Mechanisms Conference; Sanibel, Florida; organizing committee, 1981-1983
  • ACS, Ad Hoc Task Force to monitor the Journal of Organic Chemistry; 1980-1981
  • NIH, Medicinal Chemistry A Study Section; 1977-81

Editorial Activities

  • Editor-in-Chief, Journal of Organic Chemistry, 2001- present
  • Senior Editor, Journal of Organic Chemistry, 2000-2001
  • Associate Editor, Organic Letters, 1999-2001
  • Associate Editor, Journal of Organic Chemistry, 1990-1995
  • Editorial Advisory Board, Chemical Reviews, 1996-2001
  • Editorial Advisory Board, Bioorganic & Medicinal Chemistry, 1993-present
  • Editorial Advisory Board, Journal of Organic Chemistry, 1987-1990
  • Editorial Board, Journal of Bioorganic Chemistry, 1983-1990
  • Editorial Advisory Board, Journal of the American Chemical Society, 1983-1986

Publications

  • Laskovics, F.M.; Poulter, C.D. "Prenyltransferase. Determination of the Binding Mechanism and Individual Kinetic Constants for Farnesylpyrophosphate Synthetase by Rapid Quench and Isotope Partitioning Experiments." Biochemistry, 1981, 20, 1893-1901.
  • Poulter, C.D.; Wiggins, P.L.; Plummer, T.L. "Synthesis of Fluorinated Analogues of Geraniol." J. Org. Chem., 1981, 46, 1532-1538.
  • Dixit, V.M.; Laskovics, F.M.; Noall, W.I.; Poulter, C.D. "Tris-(tetra-n-butylammonium) Hydrogen Pyrophosphate. A New Reagent for the Preparation of Allylic Pyrophosphate Esters." J. Org. Chem., 1981, 46, 1967-1969.
  • Poulter, C.D.; Rilling, H.C. "Prenyl Transferases and Isomerase." In Biosynthesis of Isoprenoid Compounds; Volume 1, Chapter 4, J.W. Porter, Ed.; John Wiley & Sons: New York, 1981, pp. 162-224.
  • Poulter, C.D.; Rilling, H.C. "Conversion of Farnesyl Pyrophosphate to Squalene." In Biosynthesis of Isoprenoid Compounds; Volume 1, Chapter 8, J.W. Porter, Ed.; John Wiley & Sons: New York, 1981, pp. 414-441.
  • Poulter, C.D.; Argyle, J.C.; Mash, E.A.; Laskovics, G.M.; Wiggins, P.L.; King, C.R. "Inhibitors of Isoprenoid Biosynthesis." In Regulation of Insect Development and Behavior; Chapter 3, "Chemistry and Biochemistry of Juvenile Hormones", Wroclaw Technical University Press:, 1981, pp. 149-162.
  • Poulter, C.D.; Wiggins, P.L.; Le, A.T. "Farnesyl Pyrophosphate Synthetase. A Stepwise Mechanism for the 1'-4 Condensation Reaction." J. Am. Chem. Soc., 1981, 103, 3926-3927.
  • Mash, E.A.; Gurria, G.M.; Poulter, C.D. "Farnesyl Pyrophosphate Synthetase. Evidence for a Rigid Geranyl Cation-Pyrophosphate Anion Pair." J. Am. Chem. Soc., 1981, 103, 3927-3929.
  • King, C.-H.R.; Poulter, C.D. "Model Studies of Terpene Biosynthesis. Intermolecular 1'-2 Electrophilic Condensation of 3-Methyl-2-butenyl Acetate." J. Am. Chem. Soc., 1982, 104, 1413-1420.
  • Poulter, C.D.; King, C.-H.R. "Model Studies of Terpene Biosynthesis. Stereospecific Cyclization of N-Methyl-(S)-4-([1'-2H]neryloxy)pyridinium Methyl Sulfate to a -Terpineol." J. Am. Chem. Soc., 1982, 104, 1420-1422.
  • Poulter, C.D.; King, C.-H.R. "Model Studies of Terpene Biosynthesis. A Stepwise Mechanism for Cyclization of Nerol to a -Terpineol." J. Am. Chem. Soc., 1982, 104, 1422-1424.
  • Griffey, R.H.; Poulter, C.D.; Yamaizumi, Z.; Nishimura, S.; Hurd, R.E. "1H NMR Studies of 15N-Labeled Escherichia coli tRNAet. Use of 1J1H-15N Couplings to Identify Imino Resonances of Uridine-Related Bases." J. Am. Chem. Soc., 1982, 104, 5810-5811.
  • Griffey, R.H.; Poulter, C.D.; Yamaizumi, Z.; Nishimura, S.; Hurd, R.E. "1H NMR Studies of 15N-Labeled Escherichia coli tRNAet. An Unambiguous Assignment for the G-U Pair and Detection of a Uridine Resonance at 11.4 ppm." J. Am. Chem. Soc., 1982, 104, 5811-5813.
  • Sandifer, R.M.; Thompson, M.D.; Gaughan, R.G.; Poulter, C.D. "Squalene Synthetase. Inhibition by an Ammonium Analogue of a Carbocationic Intermediate in the Conversion of Presqualene Pyrophosphate to Squalene." J. Am. Chem. Soc., 1982, 104, 7376-7378.
  • Griffey, R.H.; Poulter, C.D.; Yamaizumi, Z.; Nishimura, S.; Hawkins, B.L. "1H NMR Studies of Nitrogen-15-Labeled Escherichia coli tRNAet. Assignments of Imino Resonances for Uridine-Related Bases by 1H-15N Heteronuclear Double Resonance Difference Spectroscopy." J. Am. Chem. Soc., 1983, 105, 143-145.
  • Griffey, R.H.; Poulter, C.D. "Efficient Syntheses of [3-15N]Uracil and [3-15N]Thymine." Nucleic Acids Research, 1983, 11, 6497-6504.
  • Griffey, R.H.; Poulter, C.D.; Bax, A.; Hawkins, B.L.; Yamaizumi, Z.; Nishimura, S. "Multiple Quantum Two-Dimensional 1H-15N Nuclear Magnetic Resonance Spectroscopy: Chemical Shift Correlation Maps for Exchangeable Imino Protons of Escherichia coli tRNAet in Water." Proc. Natl. Acad. Sci., 1983, 80, 5895-5897.
  • Griffey, R.H.; Poulter, C.D. "Detection of the Imino Hydrogen Bond in G-C Pairs by 1H and 15N Nuclear Magnetic Resonance Spectroscopy." Tetrahedron Lett., 1983, 24, 4067-4070.
  • Yang, T.-H.; Zabriskie, T.M.; Poulter, C.D. "Investigation of Isoprenoid Benzoates and Naphthoates by Reversed-Phase Liquid Chromatography. Isocratic Elution Characteristics of Benzoates and Naphthoates of C5-C20 Terpenoid Alcohols." J. Chromatography, 1984, 312, 121-132.
  • Capson, T.L.; Poulter, C.D. "A Facile Synthesis of Primary Amines from Carboxylic Acids by the Curtius Rearrangement." Tetrahedron Lett., 1984, 25, 3515-3518.
  • Dixit, V.M.; Poulter, C.D. "Convenient Syntheses of Adenosine 5'-Diphosphate, Adenosine 5'-Methylenediphosphonate, and Adenosine 5'-Triphosphate." Tetrahedron Lett., 1984, 25, 4055-4058.
  • Sagami, H.; Ogura, K.; Weiner, A.; Poulter, C.D. "Effect of Zinc Ions on Farnesyl Pyrophos-phate Synthetase Activity." Biochemistry Intl., 1984, 8, 661-667.
  • Davisson, V.J.; Woodside, A.B.; Poulter, C.D. "Synthesis of Allylic and Homoallylic Isoprenoid Pyrophosphates." Meth. Enzymol., 1985, 110, 130-144.
  • Bartlett, D.L.; King, C.-H.R.; Poulter, C.D. "Purification of Farnesyl Pyrophosphate Synthetase by Affinity Chromatography." Meth. Enzymol., 1985, 110, 171-184.
  • Yang, T.-H.; Zabriskie, T.M.; Poulter, C.D. "Reversed-Phase High Pressure Liquid Chromatography of C5 to C20 Isoprenoid Benzoates and Naphthoates." Meth. Enzymol., 1985, 111, 252-263.
  • Griffey, R.H.; Davis, D.; Yamaizumi, Z.; Bax, A.; Nishimura, S.; Hawkins, B.L.; Poulter, C.D. "15N Labeled E. coli tRNAet, tRNAGlu, tRNATyr, and tRNAPhe. Double Resonance and Two Dimensional NMR of H-N1 Units in Pseudouridine." J. Biol. Chem., 1985, 260, 9734-9741.
  • Davisson, V.J.; Neal, T.R.; Poulter, C.D. "Farnesyl Pyrophosphate Synthetase. A Case for Common Electrophilic Mechanisms for Prenyltransferases and Terpene Cyclases." J. Am. Chem. Soc., 1985, 107, 5277-5279.
  • Bartlett, D.L.; King, C.-H.R.; Poulter, C.D. "An Affinity Column for the Purification of Prenyltransferases." Anal. Biochem., 1985, 149, 507-515.
  • Heathcock, C.H.; Finkelstein, B.L.; Aoki, T.; Poulter, C.D. "Stereostructure of the Archaebacterial C40 Diol." Science, 1985, 229, 862-864.
  • Muehlbacher, M.; Poulter, C.D. "Isopentenyl Pyrophosphate: Dimethylallyl Pyrophosphate Isomerase. Irreversible Inhibition of the Enzyme by Active-Site Directed Covalent Attachment." J. Am. Chem. Soc., 1985, 107, 8307-8308.
  • Aoki, T.; Poulter, C.D. "Archaebacterial Isoprenoids. Synthesis of 2,3-Di-O-phytanyl-sn-glycerol and its 1,2-Isomer." J. Org. Chem., 1985, 50, 5634-5636.
  • Davis, D.R.; Griffey, R.H.; Yamaizumi, Z.; Nishimura, S.; Poulter, C.D. "15N Labeled tRNA. Identification of Dihydrouridine in E. coli tRNAet, tRNALys, and tRNAPhe by 1H-15N Two-Dimensional NMR." J. Biol. Chem., 1986, 261, 3584-3587.
  • Davisson, V.J.; Zabriskie, T.M.; Poulter, C.D. "Radiolabeled Allylic Isoprenoid Pyrophosphates: Synthesis, Purification, and Determination of Specific Activity." Bioorg. Chem., 1986, 14, 46-54.
  • Davisson, V.J.; Woodside, A.B.; Neal, T.R.; Stremler, K.E.; Muehlbacher, M.; Poulter, C.D. "Phosphorylation of Isoprenoid Alcohols." J. Org. Chem., 1986, 51, 4768-4779.
  • Griffey, R.H.; Davis, D.R.; Yamaizumi, Z.; Nishimura, S.; Hawkins, B.L.; Poulter, C.D. "15N Labeled tRNA. Identification of 4-Thiouridine in Escherichia coli tRNAer and tRNAyr by 1H-15N Two-Dimensional NMR Spectroscopy." J. Biol. Chem., 1986, 261, 12074-12078.
  • Davisson, V.J.; Davis, D.R.; Dixit, V.M.; Poulter, C.D. "Synthesis of Nucleotide 5'-Diphosphates from 5'-O-Tosyl Nucleosides." J. Org. Chem., 1987, 52, 1794-1801.
  • McClard, R.W.; Fujita, T.S.; Stremler, K.E.; Poulter, C.D. "Novel Phosphonylphosphinyl (P-C-P-C-) Analogs of Biochemically Interesting Diphosphates. Synthesis and Properties of P-C-P-C- Analogs of Isopentenyl Diphosphate and Dimethylallyl Diphosphate." J. Am. Chem. Soc., 1987, 109, 5544-5545.
  • Stremler, K.E.; Poulter, C.D. "Methane and Difluoromethanediphosphonate Analogs of Geranyl Diphsophate: Hydrolysis-Inert Alternate Substrates." J. Am. Chem. Soc., 1987, 109, 5542-5544.
  • Woodside, A.B.; Huang, Z.; Poulter, C.D. "Geranyl Diphosphate." Org. Syn., 1987, 66, 211-219.
  • Davisson, V.J.; Sharp, T.R.; Poulter, C.D. "Negative Ion Fast Atom Bombardment Mass Spectrometry of Isoprenoid Diphosphates and Related Analogs." Bioorg. Chem., 1988, 16, 111-123.
  • Muehlbacher, M.; Poulter, C.D. "Regioselective Opening of Simple Epoxides with Diisopropyl- amine Trihydrofluoride." J. Org. Chem., 1988, 53, 1026-1030.
  • Gmeiner, W.H.; Poulter, C.D. "An Efficient Synthesis of [8-13C]Adenine." J. Org. Chem., 1988, 53, 1322-1323.
  • Poulter, C.D.; Aoki, T.; Daniels, L. "Biosynthesis of Isoprenoid Membranes in the Methano-genic Archaebacterium Methanospirillum hungatei." J. Am. Chem. Soc., 1988, 110, 2620-2624.
  • Huang, Z.; Poulter, C.D.; Wolf, F.F.; Somers, T.C.; White, J.D. "Braunicene. A Novel Cyclic C32 Isoprenoid from Botryococcus braunii." J. Am. Chem. Soc., 1988, 110, 3959-3964.
  • Huang, Z.; Poulter, C.D. "Braunicene. Absolute Stereochemistry of the Cyclohexane Ring." J. Org. Chem., 1988, 53, 4089-4094.
  • Muehlbacher, M.; Poulter, C.D. "Isopentenyl-Diphosphate Isomerase. Inactivation of the Enzyme with Active-Site-Directed Inhibitors and Transition State Analogs." Biochemistry, 1988, 27, 7315-7328.
  • Gmeiner, W.H.; Poulter, C.D. "NMR Studies of Nucleic Acids. Deuterium Isotope Effects of 13C Chemical Shifts in Hydrogen Bonded Complexes of Pyrimidines and Purines." J. Am. Chem. Soc., 1988, 110, 7640-7647.
  • Huang, Z.; Poulter, C.D. "Isobraunicene, Wolficene, and Isowolficene. New Cyclic 1'-3 Fused Isoprenoids from Botryococcus braunii." J. Org. Chem., 1988, 53, 5390-5392.
  • Capson, T.L.; Thompson, M.D.; Dixit, V.M.; Gaughan, R.G.; Poulter, C.D. "Synthesis of Ammonium Analogs of Carbocationic Intermediates in the Conversion of Presqualene Diphosphate to Squalene." J. Org. Chem., 1988, 53, 5903-5908.
  • Huang, Z.; Poulter, C.D. "Stereochemical Studies of Botryococcene Biosynthesis: Analogies between 1'-1 and 1'-3 Condensation in the Isoprenoid Pathway." J. Am. Chem. Soc., 1989, 111, 2713-2715.
  • Davis, D.R.; Yamaizumi, Z.; Nishimura, S.; Poulter, C.D. "15N Labeled 5S RNA. Identification of Uridine Base Pairs in E. coli 5S RNA by 1H-15N Multiple Quantum NMR." Biochemistry, 1989, 28, 4105-4108.
  • Poulter, C.D.; Capson, T.L.; Thompson, M.D.; Bard, R.M. "Squalene Synthetase. Inhibition by Ammonium Analogs of Carbocationic Intermediates in the Conversion of Presqualene Diphosphate to Squalene." J. Am. Chem. Soc., 1989, 111, 3734-3739.
  • Poulter, C.D.; Muehlbacher, M.; Davis, D.R. "Isopentenyl Diphosphate Isomerase. Mechanism of Active-Site-Directed Irreversible Inhibition by 3-(Fluoromethyl)-3-butenyl Diphosphate." J. Am. Chem. Soc., 1989, 111, 3740-3742.
  • Huang, Z.; Poulter, C.D. "Tetramethylsqualene. A New Triterpene from Botryococcus braunii var. Showa." Phytochemistry, 1989, 28, 1467-1470.
  • Sherman, M.M.; Petersen, L.; Poulter, C.D. "Isolation and Characterization of Isoprene Mutants of Escherichia coli." J. Bacteriology, 1989, 171, 3619-3628.
  • Anderson, M.S.; Muehlbacher, M.; Street, I.P.; Proffitt, J.; Poulter, C.D. "Isopentenyl-Diphosphate:Dimethylallyl-Diphosphate Isomerase. An Improved Purification of the Enzyme and Isolation of the Gene from Saccharoymces cerevisiae." J. Biol. Chem., 1989, 264, 19169-19175.
  • Anderson, M.S.; Yarger, J.G.; Burck, C.L.; Poulter, C.D. "Farnesyl Diphosphate Synthetase. Molecular Cloning, Sequence, and Expression of an Essential Gene from Saccharomyces cerevisiae." J. Biol. Chem., 1989, 264, 19176-19184.
  • Huang, Z.; Poulter, C.D. "Isoshowacene. A New C31 Hydrocarbon from Botryococcus braunii var. Showa." Phytochemistry, 1989, 28, 3043-3046.
  • Mautz, D.; Davisson, V.J.; Poulter, C.D. "Synthesis of O-Geranyl (1-Thio)diphosphate." Tetrahedron Lett., 1989, 30, 7333-7336.
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