Professor Dale Poulter

Professor C. Dale Poulter

Education

  • B.S., 1964, Louisiana State University (Cum Laude)
  • Ph.D., 1967, University of California at Berkeley, with W.G. Dauben
  • Postdoctoral, 1967-69, University of California at Los Angeles, with S. Winstein

Contact

Office: HEB 2274

Phone: 801.581.6685

Email:poulter@chem.utah.edu

Awards

  • Honorary Professor, University of Queensland, Brisbande, Australia, 2002-2004
  • Repligen Award, Biological Division, American Chemical Society, 2002
  • Wilsmore Fellow, Melbourne University, 2001
  • Rosenblatt Award, University of Utah, 1999
  • Arthur C. Cope Scholar Award, American Chemical Society, 1998
  • Governor's Medal for Science and Technology, 1995
  • National Institutes of Health Merit Award, 1995
  • Fellow, American Association for the Advancement of Science, 1994
  • Utah Award, American Chemical Society, 1992
  • Ernest Guenther Award, American Chemical Society, 1991
  • Distinguished Research Award, University of Utah, 1984
  • David P. Gardner Faculty Fellow, 1983
  • Alfred P. Sloan Fellow, 1975-79
  • NIH Career Development Awardee, 1975-80
  • NIH Postdoctoral Fellow, 1967-69
  • NIH Predoctoral Fellow, 1965-67
  • Omnicron Delta Kappa, 1964
  • Phi Lambda Upsilon, 1964
  • Phi Kappa Phi, 1964

Professional Positions

  • Distinguished Professor of Chemistry, University of Utah, 1996-present
  • Chair, Department of Chemistry, University of Utah, 1995-2000
  • John A. Widtsoe Professor of Chemistry, University of Utah, 1994-present
  • Research Professor, Department of Medicinal Chemistry, University of Utah, 1978-present
  • Adjunct Professor, Department of Biochemistry, University of Utah, 1986-present
  • Professor, Department of Chemistry, University of Utah, 1978-1994
  • Director, Interdepartmental Program in Biological Chemistry, 1990-1993
  • Associate Professor, Department of Chemistry, University of Utah, 1975-1978
  • Associate Research Professor, Department of Biopharmaceutical Sciences, University of Utah, 1975-1978
  • Assistant Professor, Department of Chemistry, University of Utah, 1969-1975
  • Assistant Research Professor, Department of Biopharmaceutical Sciences, University of Utah, 1971-1975
  • Chemist, Esso Research Laboratory, Baton Rouge, Louisiana, Summer 1964
  • Chemist, PPG Chemicals, Lake Charles, Louisiana, Summers, 1962, 1963

Professional Activities

  • NAS, Bio2010, Chemistry sub-committee, 2001
  • AAAS, Member-at-Large, 2001-present
  • CS, Advisory Committee on Graduate Education, 2000-present
  • ACS, Committee on Professional Training, 1996-present
  • ACS, Councilor, Biological Division, 1993-present
  • AAAS, Nominating Committee Chemistry Division, 1997-1999, Chair 1999
  • ACS, Chair of Organic Division, 1998
  • ACS, Selection Committee; Editor of Organic Letters, 1998
  • ACS, Committee on Science, 1996-1999
  • NSF, Workshop on Organic Synthesis and Natural Products, co-organizer, 1993-1995
  • 14th Enzyme Mechanisms Conference, Scottsdale, AZ, Chair, 1993-95
  • 13th Enzyme Mechanisms Conference, Key Largo, FL, organizing committee, 1991-97
  • NIH, General Medical Sciences Council, 1990
  • ACS, American Coordinator, Biological Program, Pacific Basin Chemical Congress, 1989, 1995
  • PRF, Advisory Board, 1988-1990
  • ACS, Selection Committee; Editor of Journal of Organic Chemistry, 1988
  • ACS, Program Chairman for Biological Division, 1987
  • ACS, Canvassing Committee, Roger Adams Award in Organic Chemistry, 1986-1990
  • Gordon Conference on Enzymes, Coenzymes, and Metabolic Pathways, Chair, 1985
  • ACS, Executive Committee Organic Division, 1983-1986
  • NAS, Workshop on Effort Reporting Requirements of OMB Circular A-21; 1983
  • NIH, Ad Hoc member and Special Study Sections; 1980-1993
  • 7th Enzyme Mechanisms Conference; Sanibel, Florida; organizing committee, 1981-1983
  • ACS, Ad Hoc Task Force to monitor the Journal of Organic Chemistry; 1980-1981
  • NIH, Medicinal Chemistry A Study Section; 1977-81

Editorial Activities

  • Editor-in-Chief, Journal of Organic Chemistry, 2001- present
  • Senior Editor, Journal of Organic Chemistry, 2000-2001
  • Associate Editor, Organic Letters, 1999-2001
  • Associate Editor, Journal of Organic Chemistry, 1990-1995
  • Editorial Advisory Board, Chemical Reviews, 1996-2001
  • Editorial Advisory Board, Bioorganic & Medicinal Chemistry, 1993-present
  • Editorial Advisory Board, Journal of Organic Chemistry, 1987-1990
  • Editorial Board, Journal of Bioorganic Chemistry, 1983-1990
  • Editorial Advisory Board, Journal of the American Chemical Society, 1983-1986

Publications

  • Poulter, C.D. "Isopentenyl Diphosphate to Squalene. Enzymology and Inhibition." In The Biochemistry of Cell Walls and Membranes in Fungi; Chapter 12, P.J. Kuhn, A.P.J. Trinci, M.J. Jung, M.W. Goosey, L.G. Copping, Eds.; Springer-Verlag: Berlin, 1990, 169-188.
  • Zhang, D.L.; Daniels, L.; Poulter, C.D. "Biosynthesis of Archaebacterial Membranes. Formation of Isoprene Ethers by a Prenyl Transfer Reaction." J. Am. Chem. Soc., 1990, 112, 1264-1265.
  • Poulter, C.D. "Biosynthesis of Non-Head-to-Tail Terpenes. Formation of 1'-1 and 1'-3 Linkages." Acc. Chem. Res., 1990, 23, 70-77.
  • Street, I.P.; Poulter, C.D. "Isopentenyldiphosphate:Dimethylallyldiphosphate Isomerase: Construction of a High-Level Heterologous Expression System for the Gene from Saccharomyces cerevisiae and Identification of an Active-Site Nucleophile." Biochemistry, 1990, 29, 7531-7538.
  • Schafer, W.R.; Trueblood, C.E.; Yang, C.-C.; Mayer, M.P.; Rosenberg,S.; Poulter, C.D.; Kim, S.-H.; Rine, J. "Enzymatic Coupling of Cholesterol Intermediates to a Mating Pheromone Precursor and to the Ras Protein." Science, 1990, 249, 1133-1139.
  • Street, I.P.; Christensen, D.J.; Poulter, C.D. "Hydrogen Exchange During the Enzyme Catalyzed Isomerization of Isopentenyl Diphosphate and Dimethylallyl Diphosphate." J. Am. Chem. Soc., 1990, 112, 8577-8578.
  • Brown, M.J.; Milano, P.D.; Lever, D.C.; Epstein, W.W.; Poulter, C.D. "Prenylated Proteins. A Convenient Synthesis of Farnesyl Cysteinyl Thioethers." J. Am. Chem. Soc., 1991, 113, 3176-3177.
  • Davis, D.; Poulter, C.D. "1H-15N NMR studies of E. coli tRNAPhe from HisT Mutants: A Structural Role for Pseudouridine." Biochemistry, 1991, 30, 4223-4231.
  • Ding, V.D.-H.; Sheares, B.T.; Bergstrom, J.D.; Ponpipom, M.M.; Perez, L.B.; Poulter, C.D. "Purification and Characterization of Recombinant Human Farnesyl Diphosphate Synthetase Expressed in E. coli." Biochem. J., 1991, 275, 61-65.
  • Poulter, C.D.; Mautz, D. "Solvolysis of Allylic Phosphorothioate Esters. A Mechanistic Study of the Thiono ® Thiolo Rearrangement." J. Am. Chem. Soc., 1991, 113, 4895-4903.
  • Street, I.P.; Coffman, H.R.; Poulter, C.D. "Isopentenyl Diphosphate Isomerase. Site-Directed Mutagenesis of Cys139 Using "Counter" PCR Amplification of an Expression Plasmid." Tetrahedron, 1991, 47, 5919-5924.
  • Gebler, J.C.; Poulter, C.D. "Purification and Characterization of Dimethylallyl Tryptophan Synthase from Claviceps purpurea." Arch. Biochem. Biophys., 1992, 296, 308-313.
  • Math, S.K.; Hearst, J.E.; Poulter, C.D. "The crtE Gene in Erwinia herbicola Encodes Geranyl-geranyl Diphosphate Synthase." Proc. Natl. Acad. Sci. USA, 1992, 89, 6761-6764.
  • Gebler, J.C.; Woodside, A.B.; Poulter, C.D. "Dimethylallyltryptophan Synthase. An Enzyme Catalyzed Electrophilic Aromatic Substitution." J. Am. Chem. Soc., 1992, 114, 7354-7360.
  • Mayer, M.P.; Hahn, F.M.; Stillman, D.J.; Poulter, C.D. "Disruption and Mapping of IDI1. The Gene for Isopentenyl Diphosphate Isomerase in Saccharomyces cerevisiae." Yeast, 1992, 8, 743-748.
  • Lu, X.J.; Christensen, D.J.; Poulter, C.D. "Isopentenyl Diphosphate Isomerase. Irreversible Inhibition by 3-Methyl-3,4-epoxybutyl Diphosphate." Biochemistry, 1992, 31, 9955-9960.
  • Marrero, P.F.; Poulter, C.D.; Edwards, P.A. "Effects of Site Directed Mutagenesis of the Highly Conserved Aspartate Residues in Domain II of Farnesyl Diphosphate Synthase Activity." J. Biol. Chem., 1992, 267, 21873-21878.
  • Davisson, V.J.; Neal, T.R.; Poulter, C.D. "Farnesyl Diphosphate Synthase. Catalysis of an Intramolecular Prenyl Transfer with Bisubstrate Analogs." J. Am. Chem. Soc., 1993, 115, 1235-1245.
  • Davisson, V.J.; Poulter, C.D. "Farnesyl Diphosphate Synthase. Interplay between Substrate Topology, Stereochemistry, and Regiochemistry in Electrophilic Alkylations." J. Am. Chem. Soc., 1993, 115, 1245-1260
  • Zhang, D.L.; Poulter, C.D. "Biosynthesis of Archaebacterial Ether Lipids. Formation of Ether Linkages by Prenyltransferases." J. Am. Chem. Soc., 1993, 115, 1270-1277.
  • Chen, A.-J.; Poulter, C.D. "Purification and Characterization of Farnesyl Diphosphate/ Geranylgeranyl Diphosphate Synthase. A Thermostable Bifunctional Enzyme from Methano-bacterium thermoautotrophicum." J. Biol. Chem., 1993, 268, 11002-11007.
  • Zhang, D.; Poulter, C.D. "Biosynthesis of Archaebacterial Lipids in Halobacterium halobium and Methanobacterium thermoautotrophicum." J. Org. Chem., 1993, 58, 3919-3922.
  • Zhang, D.; Jennings, S.M.; Robinson, G.W.; Poulter, C.D. "Yeast Squalene Synthase. Expression, Purification and Characterization of Soluble Recombinant Enzyme." Arch. Biochem. Biophys., 1993, 304, 133-143.
  • Zhang, D.; Poulter, C.D. "Analysis and Purification of Phosphorylated Isoprenoids by Reversed-Phase HPLC." Anal. Biochem., 1993, 213, 356-361.
  • Mayer, M.P.; Prestwich, G.D.; Dolence, J.M.; Bond, P.D.; Wu, H.-y.; Poulter, C.D. "Protein Farnesyltransferase. Expression and Immunoaffinity Purification of the Heterodimeric Protein from Saccharomyces cerevisiae." Gene, 1993, 132, 41-47.
  • Chen, A.; Zhang, D.; Poulter, C.D. "(S)-Geranylgeranylglyceryl Phosphate Synthase. Purification and Characterization of the First Pathway-Specific Enzyme in Archaebacterial Membrane Lipid Biosynthesis." J. Biol. Chem., 1993, 268, 21701-21705.
  • Mookhtiar, K.A.; Kalinowski, S.S.; Zhang, D.; Poulter, C.D. "Yeast Squalene Synthase. A Mechanism for Addition of Substrates and Activation by NADPH." J. Biol. Chem., 1994, 269, 11201-11207.
  • Song, L.; Poulter, C.D. "Yeast Farnesyl Diphosphate Synthase. Site-Directed Mutagenesis of Residues in Highly-Conserved Prenyltransferase Domains I and II." Proc. Natl. Acad. Sci. USA, 1994, 91, 3044-3048.
  • Street, I.P.; Coffman, H.R.; Baker, J.A.; Poulter, C.D. "Identification of Cys139 and Glu207 as Catalytically Important Groups in the Active Site of Isopentenyldiphosphate:Dimethyl-allyldiphosphate Isomerase." Biochemistry, 1994, 33, 4212-4217.
  • Chen, A.; Poulter, C.D. "Isolation and Characterization of idsA. The Gene for the Short Chain Isoprenyl Diphosphate Synthase from Methanobacterium thermoautotrophicum." Arch. Biochem. Biophys., 1994, 314, 399-404.
  • Poulter, C.D.; Dolence, J.M.; Bond, P.D. "Protein Farnesyltransferase: A Mechanism of Action." J. Protein Chem., 1994, 13, 488-489.
  • Tarshis, L.C.; Yan, M.; Poulter, C.D.; Sacchettini, J.C. "Crystal Structure of Recombinant Farnesyl Diphosphate Synthase at 2.6 Angstroms" Biochemistry, 1994, 33, 10871-10877.
  • Christensen, D.J.; Poulter, C.D. "Enzymatic Synthesis of Isotopically Labeled Isoprenoid Diphosphates." Bioorg. Med. Chem., 1994, 2, 631-637.
  • Chen, A.; Kroon, P.; Poulter, C.D. "Isoprenyl Diphosphate Synthases: Protein Sequence Comparisons, A Phylogenetic Tree, and Predictions of Secondary Structure." Protein Sci., 1994, 3, 600-607.
  • Cassidy, P.B.; Dolence, J.M.; Poulter, C.D. "Continuous Fluorescence Assay for Protein Prenyltransferases." In Methods in Enzymology; P.J. Casey, J.E. Buss, Eds.; Academic Press: San Diego, 1995, Vol. 250, pp. 30-43.
  • Zhang, D.; Poulter, C.D. "Biosynthesis of Non-Head-to-Tail Isoprenoids. Syntheses of 1'-1 and 1'-3 Structures by Recombinant Yeast Squalene Synthase." J. Am. Chem. Soc., 1995, 117, 1641-1642.
  • Rogers, D.H.; Yi, E.C.; Poulter, C.D. "An Enantioselective Synthesis of (+)-Presqualene Diphosphate." J. Org. Chem., 1995, 60, 941-945.
  • Hahn, F.M.; Poulter, C.D. "Isolation of Schizosaccharomyces pombe Isopentenyl Diphosphate Isomerase cDNA Clones by Complementation and Synthesis of the Enzymes in E. coli." J. Biol. Chem., 1995, 270, 11298-11303.
  • Dolence, J.M.; Poulter, C.D. "A Mechanism for Posttranslational Modification of Proteins by Yeast Protein Farnesyl Transferase." Proc. Natl. Acad. Sci., 1995, 92, 5008-5011.
  • Stirtan, W.G.; Poulter, C.D. "Yeast Protein Geranylgeranyltransferase Type-I: Overproduction, Purification and Characterization." Arch. Biochem. Biophys., 1995, 321, 182-190.
  • Doyle, M.P; Protopopova, M.N.; Poulter, C.D.; Rogers, D.H. "Macrocyclic Lactones from Dirhodium(II) Catalyzed Intramolecular Cyclopropanation and Carbon-Hydrogen Insertion." J. Am. Chem. Soc., 1995, 117, 7281-7282.
  • Jiang, Y.; Proteau, P.; Poulter, C.D.; Ferro-Novick, S. "BTS1 Encodes a Geranylgeranyl Diphosphate Synthase Saccharomyces cerevisiae." J. Biol. Chem., 1995, 270, 21793-21799.
  • Humpf, H.-U.; Berova, N.; Nakanishi, K.; Jarstfer, M.B.; Poulter, C.D. "Allylic and Homoallylic CD Exciton Chirality: A Sensitive Method for Determining the Absolute Stereochemistry of Natural Products." J. Org. Chem., 1995, 60, 3539-3542.
  • Gibbs, R.A.; Krishna, U.; Dolence, J.; Poulter, C.D. "A Stereoselective Palladium Copper-Catalyzed Route to Isoprenoids. Synthesis and Biological Evaluation of 13-Methylidenefarnesyl Diphosphate." J. Org. Chem., 1995, 60, 7821-7829.
  • Tsai, H.-F.; Wang, H.; Gebler, J.C.; Poulter, C.D.; Schardl, C.L. "The Claviceps purpurea Gene Encoding Dimethylallyltryptophan Synthase, the Committed Step for Ergot Alkaloid Biosynthesis." Biochem. Biophys. Res. Comm., 1995, 216, 119-125.
  • Dolence, J.M.; Cassidy, P.B.; Mathis, J.R.; Poulter, C.D. "Yeast Protein Farnesyl-transferase: Steady-State Kinetic Studies of Substrate Binding." Biochemistry, 1995, 34, 16687-16694.
  • Anderson-Altmann, K.L.; Phung, C.G.; Mavromoustakos, S.; Zheng, Z.; Facelli, J.C.; Poulter, C.D.; Grant, D.M. "The 15N Chemical Shift Tensors of Uracil Determined from 15N Powder Pattern and 15N-13C Dipolar NMR Spectroscopy." J. Phys. Chem., 1995, 99, 10454-10458.
  • Dolence, J.M.; Poulter, C.D. "Synthesis of Analogs of Farnesyl Diphosphate." Tetrahedron Symposium-in-Print,, 1996, 52, 119-130.
  • Hahn, F.M.; Baker, J.A.; Poulter, C.D. "Open Reading Frame 176 in the Photosynthesis Gene Cluster of Rhodobacter capsulatus Encodes idi, a Gene for Isopentenyl Diphosphate Isomerase." J. Bacteriol., 1996, 178, 619-624.
  • Moore, J.A.; Chen, A.; Mujing, Y.; Hurlburt, A.P.; Poulter, C.D. "Identification of the gltX Gene Encoding Glutamyl-tRNA Synthetase from Methanobacterium thermoautotrophicum." Biochim. Biophys. Acta, 1996, 1305, 113-116.
  • Biller, S.A.; Neuenschwander, K.; Ponpipom, M.M.; Poulter, C.D. "Squalene Synthase Inhibitors." Current Pharm. Design, 1996, 2, 1-40.
  • Hahn, F.M.; Xuan, J.W.; Chambers, A.F.; Poulter, C.D. "Human Isopentenyl Diphosphate:Dimethylallyl Diphosphate Isomerase: Overproduction, Purification and Characterization." Arch. Biochem. Biophys., 1996, 332, 30-34.
  • Witter, D.J.; Poulter, C.D. "Yeast Geranylgeranyltransferase Type-II: Steady State Kinetic Studies of the Recombinant Enzyme." Biochemistry, 1996, 35, 10454-10463.
  • Ratemi, E.S.; Dolence, J.M.; Poulter, C.D.; Vederas, J.C. "Synthesis of Protein Farnesyltransferase and Protein Geranylgeranyl-transferase Inhibitors: Rapid Access to Chaetomellic Acid A and Its Analogues." J. Org. Chem., 1996, 61, 6296-6301.
  • Cassidy, P.B.; Poulter, C.D. "Transition State Analogs for Protein Farnesyltransferase." J. Am. Chem. Soc., 1996, 118, 8761-8762.
  • Poulter, C.D. "Mechanistic Studies of the Prenyl Transfer Reaction with Fluorinated Substrate Analogs." In Biomedical Frontiers of Fluorine Chemistry; I. Ojima, J.R. McCarthy, J.T. Welch, Eds.; ACS Symposium Series 639, 1996, 158-168.
  • Mu, Y.-Q.; Gibbs, R.A.; Eubanks, L.M.; Poulter, C.D. "Cuprate-Mediated Synthesis and Biological Evaluation of Cyclopropyl and tert-Butyl Farnesyl Diphosphate Analogs." J. Org. Chem., 1996, 61, 8010-8015.
  • Tarshis, L.C.; Proteau, P.J.; Kellogg, B.A.; Sacchettini, J.C.; Poulter, C.D. "Regulation of Product Chain Length by Isoprenyl Diphosphate Synthases." Proc. Natl. Acad. Sci. USA, 1996, 93, 15018-15023.
  • Jarstfer, M.B.; Blagg, B.S.J.; Rogers, D.H.; Poulter, C.D. "Biosynthesis of Squalene. Evidence for a Tertiary Cyclopropylcarbinyl Cationic Intermediate in the Rearrangement of Presqualene Diphosphate to Squalene." J. Amer. Chem. Soc., 1996, 118, 13089-13090.
  • Moore, J.A.; Poulter, C.D. "Escherichia coli Dimethylallyl Diphosphate: tRNA Dimethylallyltransferase." Biochemistry, 1997, 36, 604-614.
  • Stirtan, W.G.; Poulter, C.D. "Yeast protein Geranylgeranyltransferase Type-I: Steady-state Kinetics and Substrate Binding." Biochemistry, 1997, 36, 4552-4557.
  • Mathis, J.R.; Poulter, C.D. "Yeast Protein Farnesyltransferase. A Presteady-State Kinetic Analysis." Biochemistry, 1997, 36, 6367-6376.
  • Mathis, J.R.; Back, K.; Starks, C.; Noel, J.; Poulter, C.D.; Chappell, J. "A Pre-Steady State Study of Recombinant Sesquiterpene Cyclases." Biochemistry, 1997, 36, 8340-8348.
  • Dolence, J.M.; Rozema, D.M.; Poulter, C.D. "Yeast Protein Farnesyltransferase. Site-Directed Mutagenesis of Conserved Residues in the b -Subunit." Biochemistry, 1997, 36, 9246-9252.
  • Sacchettini, J.C.; Poulter, C.D. "Creating Isoprenoid Diversity." Science, 1997, 277, 1788.
  • Campbell, M.; Hahn, F.M.; Poulter, C.D.; Leustek, T. "Analysis of the Isopentenyl Diphosphate Isomerase Gene Family from Arabidopsis thaliana." Plant Molec. Biol., 1997, 36, 323-328.
  • Kellogg, B.; Poulter, C.D. "Chain Elongation in the Isoprenoid Biosynthetic Pathway." Curr. Opin. Chem. Biol., 1997, 1, 570-578.
  • Poulter, D.; Goldenberg, D. "Structure: Organic biological molecules." In Principles of Chemistry in Biology; Theil, E.C., Ed.; Am. Chem. Soc.: Washington, DC, 1998, pp. 1-49.
  • Dolence, J.M.; Poulter, C.D. "Electrophilic Alkylations, Isomerizations, and Rearrangements." In Comprehensive Natural Products Chemistry; Meth-Cohn, O., Ed.; Elsevier: Oxford, 1998,Vol. 5, pp. 18473-18500.
  • Koohang, A.; Coates, R.M.; Owen, D.; Poulter, C.D. "Synthesis and Evaluation of Aziridine Analogs of Presqualene Diphosphate as Squalene Synthase Inhibitors," J. Org. Chem., 1999, 64, 6-7.
  • Blagg, B.S.J.; Poulter, C.D. "Synthesis of 1-Deoxy-D-xylulose and 1-Deoxy-D-xylulose-5-phosphate," J. Org. Chem., 1999, 64, 1508-1511.
  • Leyes, A.E.; Baker, J.A.; Hahn, F.M.; Poulter, C.D. "Biosynthesis of Isoprenoids in Escherichia coli: Stereochemistry of the Reaction Catalyzed by Isopentenyl Diphosphate:Dimethylallyl Diphosphate Isomerase," Chem. Comm., 1999, 717-718.
  • Hahn, F.M.; Hurlburt, A.P.; Poulter, C.D. "Escherichia coli Open Reading Frame 6961 is idi, a Non-Essential Gene Encoding Isopentenyl Diphosphate Isomerase," J. Bacteriology, 1999, 181, 4499-4504.
  • Wu, Z.; Demma, M.; Strickland, C.L.; Radisky, E.S.; Poulter, C.D.; Le, H.V.; Windsor, W.T. "Farnesyl Protein Transferase: Identification of K164a and Y300b as Catalytic Residues by Mutagenesis and Kinetic Studies", Biochemistry, 1999, 38, 11239-11249.
  • Rozema, D.B.; Phillips, S.T.; Poulter, C.D. " Yeast Protein Farnesyltransferase. Binding of S-Alkyl Peptides and Related Analogs", Org Lett, 1999, 1, 815-817.
  • Leyes, A.E.; Poulter, C.D. "Synthesis of (R)-[2-2H]isopentenyl Diphosphate and Determination of Its Enantiopurity by 2H NMR Spectroscopy in a Lyotropic Medium", Org Lett, 1999, 1, 1067-1070.
  • Leyes, A.E.; Baker, J.A.; Poulter, C.D. "Biosynthesis of Isoprenoids in E. coli: Stereochemistry of the Reaction Catalyzed by Farnesyl Diphosphate Synthase", Org Lett, 1999, 1, 1071-1073.
  • Rozema, D.B.; Poulter, C.D. "Yeast protein Farnesyltransferase. pKas of Peptide Substrates Bound as Zinc Thiolates" Biochemistry, 1999, 38, 13138-13146.
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