PUBLICATIONS
1. Cuypers, E.; Abdel-Mottaleb, Y.; Rainier, J. D.; Tytgat, J. “Gambierol, A Toxicon Produced by the Gambierdiscus toxicus, is a Potent blocker of Voltage-Gated Potassium Channels,” Toxicon, 2008, in press.
2. Cao, Z.; George, J.; Gerwick, W. H.; Baden, D. G.; Rainier, J. D.; Murray, T. F. “Influence of Lipid Soluble Gating Modifier Toxins on Sodium Influx in Neocortical Neurons,” Submitted.
3. Alan R. Light, Ronald W. Hughen, Jie Zhang, Jon Rainier, Zhuqing Liu, and Jeewoo Lee “Dorsal root ganglion neurons innervating skeletal muscle respond to physiological combinations of protons, ATP and lactate mediated by ASIC, P2X and TRPV1,” Submitted.
4. Iyer, K.; Rainier, J.D. “Olefinic-Ester and Diene Ring-Closing Metathesis Using a Reduced Titanium Alkylidene,” J. Am. Chem. Soc. 2007, 129, 12604.
5. Cuypers, E.; Yanagihara, A.; Rainier, J.D.; Tytgat, J. “TRPV1 as a key determinant in ciguatera and neurotoxic shellfish poisoning,” Biochem. Biophys. Res. Commun. 2007 361, 214.
6. LePage, K.T.; Rainier, J.D.; Johnson, H.W.B.; Baden, D.G.; Murray, T.F. “Gambierol Acts as a Functional Antagonis of Neurotoxin Site 5 on Voltage-Gated Sodium Channels in Cerebellar Granule Neurons,” J. Pharm. Exp. Therap. 2007, 323, 174.
7. Roberts, S.W.; Rainier, J.D. “The Synthesis of an A-E Gambieric Acid Subunit using a C-Clycoside Centered Strategy,” Org. Lett. 2007, 9, 227.
8. Orendt, A.M.; Roberts, S.W.; Rainier, J.D. “The Role of Asynchronous Bond Formation in the Diastereoselective Epoxidation of Cyclic Enol Ethers: A Density Functional Theory Study,” J. Org. Chem. 2006, 71, 5565. PDF
9. Sabahi, A.; Novikov, A.; Rainier, J.D. “2-Thioindoles as Precursors to Spiro-Fused Indolines: Synthesis of (±)-Dehaloperophoramidine,” Angew. Chem. Int. Ed. 2006, 45, 4317. PDF
10. Majumder, U.; Cox, J.M.; Johnson, H.W.B.; Rainier, J.D. “The Total Synthesis of Gambierol. The Generation of the A-C and F-H Subunits Using a C-Glycoside Centered Strategy,” Chem. Eur. J. 2006, 12, 1736. PDF
11. Johnson, H.W.B.; Majumder, U.; Rainier, J.D. “The Total Synthesis of Gambierol. Subunit Coupling and Completion,” Chem. Eur. J. 2006, 12, 1747. PDF
12. Liu, Z.; Rainier, J.D. “Ring-Opening/ring-Closing Metathesis (RORCM) Reactions of 7-Azanorbornene Derivatives. An Entry into Perhydroindolines,” Org. Lett. 2006, 8, 459. PDF
13. Majumder, U.; Rainier, J.D. “Olefinic-ester cyclizations using Takai-Utimoto reduced titanium alkylidenes,” Tetrahedron Lett. 2005, 46, 7209. PDF
14. Roberts, S.W.; Rainier, J.D. "Substitution and Remote Protecting Group Influence on the Oxidation/Addition of a-Substituted 1,2-Anhydroglycosides: A Novel Entry into C-Ketosides,” Org. Lett. 2005, 7, 1141. PDF
15. Johnson, H.W.B.; Majumder, U.; Rainier, J.D.* “The Total Synthesis of Gambierol,” J. Am. Chem. Soc. 2005, 127, 848. PDF
16. Liu, Z.; Rainier, J.D. “Regioselective Ring-Opening/Cross-Metathesis Reactions of Norbornene Derivatives with Electron Rich Olefins,” Org. Lett. 2005, 7, 131. PDF
17. Nyong, A.; Rainier, J.D. “The diastereoselective synthesis of quaternary substituted thioindolines from sulfur ylide intermediates,” J. Org. Chem. 2005, 70, 746. PDF
18. Weerasakere, M.; Liu, Z.; Rainier, J.D. “Highly Regioselective Ring-Opening/Cross-Metathesis Reactions of 2-Sulfonylnorbornene Derivatives,” Org. Lett. 2004, 6, 1625. PDF
19. Smith, A.B., III; Kanoh, N.; Ishiyama, H.; Minakawa, N.; Rainier, J.D.; Hartz, R.A.; Cho, Y.S.; Cui, H.; Moser, W.H. “The Total Synthesis of (-)-Penitrem D,” J. Am. Chem. Soc. 2003, 125, 8228.
20. Novikov, A.N.; Kennedy, A.R.; Rainier, J.D. “Sulfur Ylide Initiated Thioclaisen Rearrangements. The Synthesis of Highly Substituted Indolines,” J. Org. Chem. 2003, 68, 993-996. PDF
21. Novikov, A.N.; Sabahi, A.; Nyong, A.M.; Rainier, J.D. “The diastereoselective Synthesis of Quaternary Substituted Indolines from Sulfur Ylide Intermediates,” Tetrahedron Asymm. 2003 1, 911-915. PDF
22. Majumder, U.; Cox, J.M.; Rainier, J.D. “Synthesis of an F-H Gambierol Subunit Using a C-Glycoside Centered Strategy,” Org. Lett. 2003 5, 913-916. PDF
23. Weerasakere, M.; Xu, Q.; Rainier, J.D. “An Anionic Condensation and Fragmentation Approach to 3-Pyrrolines” Tetrahedron Lett. 2002, 43, 8913. PDF
24. Allwein, S.P.; Cox, J.M.; Howard, B.E.; Johnson, H.W.B.; Rainier, J.D. “C-Glycosides to Fused Polycyclic Ethers” Tetrahedron 2002, 58, 1997. PDF
25. Imbriglio, J.E.; Rainier, J.D. “[2+2+1] Cycloadditions of Ynol Ethers. The Synthesis of Iron Complexes of 3-Alkoxycyclopentadienones” Tetrahedron Lett. 2001, 42, 6987. PDF
26. Cox, J.M.; Rainier, J.D. “C-Glycosides to Fused Polycyclic Ethers. An Efficient Entry into the A-D Ring System of Gambierol,” Org. Lett. 2001, 3, 2919. PDF
27. Xu, Q.; Weeresakare, M.; Rainier, J.D. “Anionic Ring Expansion Reactions of Oxabicyclo[4.2.1]heptenones. An Efficient Entry into the Carbon Framework of Oxygenated Cembranoids,” Tetrahedron 2001, 57, 8029. PDF
28. Kennedy, A.R.; Taday, M.H.; Rainier, J.D. “The Use of Sulfur Ylides in the Synthesis of Substituted Indoles,” Org. Lett. 2001, 3, 2407. PDF
29. Rainier, J.D.; Cox, J.M.; Allwein, S.P. "Enol Ether-Olefin Ring Closing Metathesis Using the Grubbs Ruthenium Imidazole Catalyst," Tetrahedron Lett. 2001, 42, 179. PDF
30. Rainier, J.D.; Allwein, S.P.; Cox, J.M. "C-Glycosides to Fused Polyethers. A Formal Synthesis of (±)-Hemibrevetoxin B," J. Org. Chem. 2001, 66, 1380. PDF
31. Rainier, J.D. and Smith, A.B., III "Polyene Cyclizations to Indole Diterpenes. The First Synthesis of (+)-Emindole SA Using a Biomimetic Approach," Tetrahedron Lett. 2000, 41, 9419.
32. Rainier, J.D.; Kennedy, A.R. "Cascades to Substituted Indoles," J. Org. Chem. 2000, 65, 6213. PDF
33. Rainier, J.D.; Imbriglio, J.I. "The Synthesis and Chemoselective Reactivity of 3-Aminocyclopentadienones," J. Org. Chem. 2000, 65, 7272. PDF
34. Rainier, J.D.; Cox, J.M. "Aluminum and Boron Mediated C-Glycoside Synthesis From 1,2-Anhydroglycosides," Org. Lett 2000, 2, 2707. PDF
35. Rainier, J.D.; Allwein, S.P.; Cox, J.M. “A Highly Efficient Synthesis of the Hemibrevetoxin B Ring System,” Org. Lett. 2000, 2, 231-234. PDF
36. Rainier, J.D.; Imbriglio, J.E. “The Synthesis and Chemoselective Reactivity of 3-Aminocyclopentadienones,” Org. Lett. 1999, 1, 2037-2039. PDF
37. Rainier, J.D.; Xu, Q. “Anionic Two-Carbon Ring Expansions of Oxabicyclo[2.2.1]heptenes and Oxabicyclo[4.2.1]nonenes,” Org. Lett. 1999, 1, 1161-1163. PDF
38. Smith, A.B., III; Kanoh, N.; Minakawa, N.; Rainier, J.D.; Blase, F.R.; Hartz, R.A. “Tremorgenic Indole Alkaloids. Studies Directed Towards the Assembly of the A, F, and I Rings of Penitrem D: Observation of an Unexpected Stereochemical Outcome,” Org. Lett. 1999, 1,1263-1266.
39. Rainier, J.D.; Kennedy, A.R.; Chase E. “An Isonitrile-Alkyne Cascade to Di-Substituted Indoles,” Tetrahedron Lett. 1999, 40, 6325-6327. PDF
40. Rainier, J.D.; Xu, Q. “A Novel Anionic Condensation, Fragmentation, and Elimination Reaction of Bicyclo[2.2.1]heptenone Ring Systems,” Org. Lett. 1999, 1, 27.
41. Rainier, J.D.; Allwein, S.P."A Highly Efficient Iterative Approach to Fused Ether Ring Systems," Tetrahedron Lett.1998, 39, 9601-9604. PDF
42. Rainier, J.D.; Allwein, S.P "An Iterative Approach to Fused Ether Ring Systems," J. Org. Chem. 1998, 63, 5310-5311. PDF
43. Smith, A.B., III; Hartz, R.A.; Spoors, P.G; Rainier, J.D. "Tremorgenic Indole Alkaloid Studies. 10. An Improved Asymmetric Synthesis of a Tricyclic Common Intermediate," Israel J. Chem. 1997, 37, 69-90.
44. Angle, S.R.; Rainier, J.D.; Woytowicz, C. "Synthesis and Chemistry of Quinone Methide Models for the Anthracycline Antitumor Antibiotics," J. Org. Chem. 1997, 62, 5884-5892.
45. Angle, S.R.; Arnaiz, D.O.; Boyce, J.P.; Frutos, R.P.; Louie, M.S.; Mattson-Arnaiz, H.L.; Rainier, J.D.; Turnbull, K.D.; Yang, W. "Formation of Carbon-Carbon Bonds via Quinone Methide-Initiated Cyclization Reactions," J. Org. Chem. 1994, 59, 6322-6337.
46. Angle, S.R.; Rainier, J.D. "Reductive Cyclization of Quinone Methides," J. Org. Chem. 1992, 57, 6883-6890.
47. Nakayama, K.; Rainier, J.D."Synthesis of (2R, 3R)-1,4-Dimethoxy-1,1,4,4-Tetraphenyl-2,3-Butanediol: A New C2-Symmetric Vicinal Diol From Dimethyl L-Tartrate," Tetrahedron 1990, 46, 4165-4170.