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Contact Information

Matthew S. Sigman
315 So. 1400 E. Rm. 4253A
Salt Lake City, UT 84112
Office: (801) 585-0774

Group News

Anat Milo's report in Nature was featured on the University of Utah website, in C&E News, and on the following science websites: Science360,, Eureka! Science News, Science 2.0, Laboratory Equipment, Science Codex, EurekAlert, Phys.Org, Newswise, Chemicals Technology, Daily News.

The Sigman group put together a short video about why they love chemistry!

Congratulations to Elizabeth Bess and Anat Milo for winning the IUPAC Poster Prize and to Vaneet Saini for winning the Strem Poster Prize at this year's OMCOS conference!

Erik Werner's report in Science was featured in the Perspectives section of Science and in C&E News.

Kaid Harper's report in Science was featured in the Perspectives section of Science, on the University of Utah home page, in the Deseret News, and in C&E News.

Erik Werner's paper in JACS was highlighted in the December 2010 issue of Synfacts.

Matthew Sigman received the 2010 Arthur C. Cope Scholar Award.

Brian Michel's paper in JACS was highlighted in the August 2009 issue of Synfacts.

Matthew Sigman received the 2009 Robert W. Parry Teaching Award


Campus Overview

Recent Research Highlights

Stokes, B.J.; Bischoff, A.J.; Sigman, M.S. "Pd(quinox)-catalyzed allylic relay Suzuki reactions of secondary homostyrenyl tosylates via alkene-assisted oxidative addition" Chem. Sci. 2014, ASAP.

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Milo, A.; Bess, E.N.; Sigman, M.S. "Interrogating selectivity in catalysis using molecular vibrations" Nature 2014, 507, 210-214.

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DeLuca, R.J.; Stokes, B.J.; Sigman, M.S. "The strategic generation and interception of palladium-hydrides for use in alkene functionalization reactions" Pure Appl. Chem. 2014, 86, 395-408.

Xu, L.; Hilton, M.J.; Zhang, X.; Norrby, P.-O.; Wu, Y.-D.; Sigman, M.S.; Wiest, O. "Mechanism, Reactivity and Selectivity in Palladium-Catalyzed Redox-Relay Heck Arylations of Alkenyl Alcohols" J. Am. Chem. Soc. 2014, 136, 1960-1Image for publication 98967.

Saini, V.; Stokes, B.J.; Sigman, M.S. "Transition-Metal-Catalyzed Laboratory-Scale Carbon-Carbon Bond-Forming Reactions of Ethylene" Angew. Chem. Int. Ed. 2013, 52, 11206-11220.

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Saini, V.; Liao, L.; Wang, Q.; Jana, R.; Sigman, M.S. "Pd(0)-Catalyzed 1,1-Diarylation of Ethylene and Allylic Carbonates" Org. Lett. 2013, 15, 5008-5011.

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Gligorich, K.M.; Vaden, R.M.; Shelton, D.N.; Wang, G.; Matsen, C.B.; Looper, R.E.; Sigman, M.S.; Welm, B.E. "Development of a Screen to Identify Selective Small Molecules Active Against Patient-Derived Metastatic and Chemoresistant Breast Cancer Cells" Breast Cancer Research 2013, 15.

Mei, T.-S.; Werner, E.W.; Burckle, A.J.; Sigman, M.S. "Enantioselective Redox-Relay Oxidative Heck Arylations of Acyclic Alkenyl Alcohols Using Boronic Acids" J. Am. Chem. Soc. 2013, 135, 6830-6833.

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Harper, K.C.; Sigman, M.S. "Using Physical Organic Parameters to Correlate Asymmetric Catalyst Performance" J. Org. Chem. 2013, 78, 2813-2818.

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McCammant, M.S.; Liao, L.; Sigman, M.S. "Palladium-Catalyzed 1,4-Difunctionalization of Butadiene To Form Skipped Polyenes" J. Am. Chem. Soc. 2013, 135, 4167-4170.

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Harper, K.C.; Vilardi, S.C.; Sigman, M.S. "Prediction of Catalyst and Substrate Performance in the Enantioselective Propargylation of Aliphatic Ketones by a Multidimensional Model of Steric Effects" J. Am. Chem. Soc. 2013, 135, 2482-2485.

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Bess, E.N.; Sigman, M.S. "Distinctive Meta-Directing Group Effect for Iridium-Catalyzed 1,1-Diarylalkene Enantioselective Hydrogenation" Org. Lett. 2013, 15, 646-649.

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DeLuca, R.J.; Edwards, J.L.; Steffens, L.D.; Michel, B.W.; Qiao, X.; Zhu, C.; Cook, S.P.; Sigman, M.S. "Wacker-Type Oxidation of Internal Alkenes using Pd(Quinox) and TBHP" J. Org. Chem. 2013, 78, 1682-1689.

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DeLuca, R.J.; Sigman, M.S. "The Palladium-Catalyzed Anti-Markovnikov Hydroalkylation of Allylic Alcohol Derivatives" Org. Lett. 2013, 15, 92-95.

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